G6PD deficiency among a particular group of people in Terai

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Original Article
Population Based Survey of Glucose-6-Phosphate Dehydrogenase(G6PD) Deficiency among People Living in Terai Districts of Nepal
Niraj Lamichhane1, Nabaraj Adhikari2, Upendra Thapa Shrestha 2, Komal Raj Rijal2, Megha Raj Banjara2, Prakash Ghimire2*
1 Department of Microbiology, Kantipur College of Medical Science, Sitapaila, Kathmandu
2 Central Department of Microbiology, Tribhuvan University, Kirtipur, Kathmandu
*Corresponding Author:Dr. Prakash Ghimire; Central Department of Microbiology, Tribhuvan University, Kirtipur, Kathmandu; Email: prakash.ghimire@microbiotu.edu.np

ABSTRACT
Objective: This study was carried out to determine the prevalence of Glucose-6-phosphate dehydrogenase (G6PD) deficiency among population of selected malaria endemic districts in central and eastern terai of Nepal.
Methods: Six hundred seventy whole blood samples were collected from the indigenous peoples community, identified based on district public health office records for G6PDd in the past from   Jhapa, Morang and Dhanusha districts endemic to malaria, during April to June 2013. Collected blood samples were tested on the sites by using BinaxNow G6PD test kit and CareStartTMG6PD test kits.
Results: The G6PD deficiency was found to be 6.1% and 6.3% in BinaxNow and CareStartTM respectively. In 42 G6PD deficient cases, male to female ration was almost equal. Higher proportions of deficient cases were from Rajbanshi and Santhal communities, than others. Highest number of deficient cases was in Jhapa followed by Morang and Dhanusha districts respectively.
Conclusion: G6PD deficiency in indigenous population groups in eastern and central terai are heterogenous, so testing of G6PD before initiation of radical treatment for P vivax infection would be important for reducing the risk of hemolysis following PQ administration, and rational evidence based PQ administration may be helpful in contributing towards elimination of malaria from the country.

Key words: G6PD, BinaxNow G6PD  and CareStartTM G6PD

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https://microbiotu.edu.np/index.php/journals/

For Citation: Lamichhane et al., 2017 TUJM Vol 4(1): 73-78

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